Transfusion-related adverse events often show a severe clinical course due to pre-existing conditions in patients. Immunocompromised patients such as bone marrow transplant and hematology/oncology patients have a high risk of developing a severe sepsis or septic shock. The mortality rate for such cases, which often result in multiple organ failure, is very high, ranging from 40% to 60%.
Impact of Transfusion Transmitted Bacteria:
Multiplicative Impact of One Contaminted Donation1
Reactions to Contaminated Platelets can Vary by Recipient
2 Fatal and 1 Severe Transfusion Reaction from 1 Donation
1. Fleischmann C, Thomas-Rueddel DO, Hartmann M, et al. Hospital Incidence and Mortality Rates of Sepsis. Deutsches Arzteblatt international 2016;113:159-66.