INTERCEPT PLATELETS
Pathogen Reduction
Safe blood is critical to improving patient outcomes…
but the continued risk of transfusion-transmitted infections (TTIs) from bacteria and emerging pathogens as well as blood shortages have brought global attention to the importance of blood safety and availability.
Robust, broad-spectrum pathogen reduction*
Platelets treated with the INTERCEPT® Blood System Pathogen Reduction System (INTERCEPT Platelets) go beyond bacteria through the inactivation of viruses, protozoa, and leukocytes, reducing the risk of TTI, including sepsis, and transfusion-associated graft-versus-host disease (TA-GVHD).1
Gram-Negative Bacteria
Viruses
Protozoa
T-Cells/Leucocytes
Bacteria
Gram-negative, Gram-positive, spirochetes
Viruses
Enveloped, Non-enveloped
- Klebsiella pneumoniae†‡
- Escherichia coli†‡
- Serratia marcescens†‡
- Yersinia entreocolitica†‡
- Staphylococcus epidermidis†‡
- Staphylococcus aureus†‡
- Streptococcus pyogenes†‡
- Bacillus cereus (vegetative)†‡
- Clostridium perfringens (vegetative)†‡
- Propionibacterium acnes†‡
- Treponema pallidum (Syphillis)†‡
- Borrelia burgdoferi (Lyme disease)†‡
- HIV-1 IIIB, cell-associated†‡
- DHBV (model virus for HBV)†‡
- BVDV (model virus for HCV)†‡
- HTLV-I†
- HTLV-II†
- West Nile virus (WNV)†‡
- Chikunguyna virus (CHIKV)†‡
- Dengue virus (DENV)†‡
- Cytomegalovirus (CMV)†
- Pseudorabies virus (model for CMV)‡
- Influenza A virus†
- Bluetongue virus (model for non-enveloped virus)†‡
Protozoan Parasites
Leukocytes
- Plasmodium falciparum†‡
- Babesia microti†‡
- Trypanosoma cruzi†‡
- Human T-Cells†‡
PROACTIVE APPROACH
Targeting DNA and RNA to prevent replication
The INTERCEPT Blood System uses amotosalen, a well-characterized photoactive compound that targets DNA and RNA, followed by UVA illumination which irreversibly cross-links nucleic acids. In doing so, the INTERCEPT treatment blocks replication of bacteria, viruses, and parasites, rendering them inactive.2
INTERCEPT Blood System Mechanism of Action
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The INTERCEPT Blood System Mechanism of Action
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*There is no pathogen reduction process that has been shown to eliminate all pathogens. Certain non-enveloped viruses (e.g., HAV, HEV, B19, and poliovirus) and Bacillus cereus spores have demonstrated resistance to the INTERCEPT process. For a full list of pathogens, see Package Insert.
References:
- The INTERCEPT Blood System for Platelets Package Insert, Cerus Corporation.
- Wollowitz, S. Seminars in Hematology. 2001. 38 (Suppl 11): p4-11.