This site provides INTERCEPT product information for Health Care Professionals in the United States.

Was it the Platelets?

Reduce Patient Risk of Transfusion-Associated Sepsis

Significantly reduce your patient’s risk of transfusion-associated sepsis with The INTERCEPT® Blood System for Platelets

According to the FDA, platelet components are uniquely vulnerable to bacterial outgrowth because of their room temperature storage and are associated with a higher risk of sepsis and related fatality than other transfusable components.1
  • Conventional platelets are susceptible to bacterial contamination
    • Room temperature storage facilitates bacterial growth
    • Sensitivity of primary culture is only 26-44% 2-4
    • Utility of secondary testing is constrained by its limit of detection5a
  • Sepsis and bacterial infections attributed to platelets are underrepresented due to passive reporting6
  • Hospital-acquired infections are associated with platelet transfusions7
  • Colonized central lines can be caused by contaminated platelets8
Was it the Platelets?

a. minimum of 1000 bacterial colony forming units/mL
1. Bacterial Risk Control Strategies for Blood Collection Establishments and Transfusion Services to Enhance the Safety and Availability of Platelets for Transfusion: FDA Guidance for Industry, December 2020. 2. Murphy, W.G., et al., Vox Sang, 2008. 95(1): p. 13-19. 3. Dumont, L.J., et al., Transfusion, 2010. 50: p. 589-599. 4. Pearce, S., G.P. Rowe, and S.P. Field, Transfus Med, 2011. 21(1): p. 25-32. 5. Platelet PGD® Test [Package Insert], April, 2017, Verax Biomedical: Marlborough, MA. 6. Hong, H., et al., Blood, 2016. 127(4): p. 496-502. 7. Aubron, C., et al., Critical Care 2017. 21(1): p. 2. 8. Yousif, A., M. Jamal, and I. Raad, Adv Exp Med Biol, 2015. 830: p. 157-79.